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AbhimanyuMandal/README.md

Abhimanyu Mandal Banner

Hi, I'm Abhimanyu Mandal πŸ‘‹

Computational Biologist β€’ Bioinformatics Researcher β€’ Healthcare Data Scientist

Building reproducible computational methods for genomics, precision medicine, and healthcare analytics.

Passionate about translating complex biomedical data into clinically meaningful insights using bioinformatics, machine learning, and statistical modeling.


πŸ‘¨β€πŸ”¬ About Me

I am a Computational Biologist with an integrated B.Tech + M.Tech in Pharmaceutical Engineering & Technology from IIT (BHU), Varanasi.

I develop computational pipelines that transform complex biomedical and healthcare data into meaningful biological and clinical insights through bioinformatics, machine learning, statistics, and data visualization.

My work spans genomics, transcriptomics, infectious disease modeling, healthcare analytics, and AI-driven biomedical research, with a strong focus on reproducible and scalable computational workflows.


πŸš€ Quick Facts

πŸŽ“ Integrated B.Tech + M.Tech β€” IIT (BHU), Varanasi

πŸ”¬ Former Project Research Assistant β€” IIT Bombay

πŸ‡¨πŸ‡¦ Former Mitacs Globalink Research Intern β€” Western University, Canada

🧬 Interested in Computational Biology, Cancer Genomics & Precision Medicine

πŸ“ Bangalore, India

πŸ’Ό Open to Full-Time Opportunities


πŸ”¬ Research Interests

  • Computational Biology
  • Bioinformatics
  • Cancer Genomics
  • RNA-seq Analysis
  • Single-cell RNA Sequencing
  • Clinical Genomics
  • Precision Medicine
  • Infectious Disease Analytics
  • Machine Learning for Healthcare
  • AI in Biomedical Research

πŸ’» Technical Skills

Programming Languages

Domain Technologies
Bioinformatics Seurat β€’ DESeq2 β€’ GATK β€’ STAR β€’ Cell Ranger β€’ IGV
Workflow Management Nextflow β€’ Snakemake β€’ Docker β€’ Git
Machine Learning Scikit-learn β€’ SVM β€’ Statistical Modeling
Visualization Tableau β€’ ggplot2 β€’ Plotly β€’ Matplotlib β€’ R shiny
Databases ClinVar β€’ gnomAD β€’ TCGA

⭐ Featured Projects

🧬 Germline Variant Analysis Pipeline

Python β€’ GATK β€’ Variant Annotation β€’ Clinical Genomics

Developed a reproducible germline variant analysis pipeline for processing next-generation sequencing data, including variant calling, annotation, filtering, and interpretation using clinically relevant genomic databases.

πŸ”— Repository


πŸŽ— Breast Cancer scRNA-seq Analysis

R β€’ Seurat β€’ Single-cell Transcriptomics

Performed single-cell RNA sequencing analysis to characterize tumor heterogeneity, identify marker genes, and investigate the tumor microenvironment. Developed computational workflows integrating transcriptomics and pathway analysis to prioritize therapeutic candidates for breast cancer.

πŸ”— Repository


🦠 Tuberculosis Spatial Risk Modeling

R β€’ Bayesian Statistics β€’ Spatial Epidemiology

Developed Bayesian disease mapping models to identify tuberculosis hotspots and quantify spatial risk patterns for public health decision-making.

πŸ”—Repository


🧠 Neurotoxicity Prediction using Machine Learning

Python β€’ Scikit-learn β€’ Support Vector Machine (SVM) β€’ Feature Engineering

Developed and evaluated machine learning models to predict neurotoxicity risk from biomedical data. Optimized feature engineering and model performance, achieving 83% classification accuracy using a Support Vector Machine (SVM), demonstrating the application of AI to predictive toxicology.

πŸ”—Repository


πŸ₯ Healthcare Claims Analytics

R β€’ Tableau

Developed an end-to-end healthcare analytics platform for insurance claims analysis, fraud detection, settlement efficiency, and provider performance evaluation.

πŸ”— Repository

πŸ“ˆ Dashboard


πŸ’Ό Research Experience

πŸ”¬ Project Research Assistant | IIT Bombay

  • Developed Bayesian spatial disease mapping models to identify tuberculosis hotspots.
  • Integrated epidemiological, demographic, and geospatial datasets for public health analysis.
  • Applied statistical modeling to support evidence-based disease surveillance.

πŸ‡¨πŸ‡¦ Mitacs Globalink Research Intern | Western University

  • Developed computational workflows for breast cancer drug repurposing.
  • Analyzed single-cell RNA sequencing datasets using Seurat.
  • Performed transcriptomic and pathway analyses to identify therapeutic targets.

🌱 Currently Working On

  • 🧬 RNA-seq Analysis Pipelines
  • πŸ€– Machine Learning for Precision Medicine
  • πŸ“Š Healthcare Data Analytics
  • 🧠 AI Applications in Computational Biology
  • πŸ“¦ Reproducible Bioinformatics Workflows

🀝 Let's Connect

Portfolio Β Β β€’Β Β  LinkedIn Β Β β€’Β Β  Email


"Transforming biomedical data into actionable insights through reproducible computational research."

Pinned Loading

  1. HER2-Luminal-Breast-Cancer-Drug-Repurposing HER2-Luminal-Breast-Cancer-Drug-Repurposing Public

    Computational drug repurposing for HER2+ luminal breast cancer using scRNA-seq disease signatures, LINCS connectivity, and cross-cell-line validation.

    R

  2. nextflow-germline-variant-pipeline nextflow-germline-variant-pipeline Public

    A modular Nextflow DSL2 pipeline implementing the GATK Best Practices for germline variant discovery from FASTQ preprocessing to functional variant annotation using Ensembl VEP.

    Nextflow 1

  3. nextflow-ngs-qc-pipeline nextflow-ngs-qc-pipeline Public

    A modular Nextflow DSL2 pipeline for automated NGS quality control using FastQC and MultiQC.

    Nextflow

  4. germline-variant-analysis-pipeline germline-variant-analysis-pipeline Public

    End-to-end Whole Exome Sequencing (WES) germline variant analysis pipeline using FastQC, BWA-MEM, SAMtools, GATK, VEP and R.

    R

  5. Neurotoxicity-Prediction-ML Neurotoxicity-Prediction-ML Public

    An end-to-end cheminformatics and machine learning pipeline for neurotoxicity prediction using PubChem, RDKit molecular descriptors, and supervised learning models.

    Python

  6. healthcare-claims-analytics healthcare-claims-analytics Public

    End-to-end healthcare claims analytics using R and Tableau to uncover operational insights, fraud patterns, and business intelligence from insurance claims data.

    R