diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
index 2c957d3aff74..16765afbcf0c 100644
--- a/.github/workflows/release.yml
+++ b/.github/workflows/release.yml
@@ -63,6 +63,10 @@ jobs:
             target: aarch64-unknown-linux-gnu
             strip: aarch64-linux-gnu-strip
             build-flags: --use-napi-cross
+          - os: ubuntu-latest
+            target: s390x-unknown-linux-gnu
+            strip: s390x-linux-gnu-strip
+            build-flags: --use-napi-cross
           - os: ubuntu-latest
             target: armv7-unknown-linux-gnueabihf
             strip: arm-linux-gnueabihf-strip
@@ -105,6 +109,12 @@ jobs:
           sudo apt-get update
           sudo apt-get install binutils-aarch64-linux-gnu -y
 
+      - name: Install binutils-s390x-linux-gnu
+        if: ${{ matrix.target == 's390x-unknown-linux-gnu' }}
+        run: |
+          sudo apt-get update
+          sudo apt-get install binutils-s390x-linux-gnu -y
+
       - uses: mlugg/setup-zig@d1434d08867e3ee9daa34448df10607b98908d29 # v2
         if: ${{ contains(matrix.target, 'musl') }}
         with:
@@ -275,6 +285,7 @@ jobs:
           cp bindings-aarch64-unknown-linux-musl/* ./npm/linux-arm64-musl/
           cp bindings-armv7-unknown-linux-gnueabihf/* ./npm/linux-arm-gnueabihf/
           cp bindings-x86_64-unknown-linux-gnu/* ./npm/linux-x64-gnu/
+          cp bindings-s390x-unknown-linux-gnu/* ./npm/linux-s390x-gnu/
           cp bindings-x86_64-unknown-linux-musl/* ./npm/linux-x64-musl/
           cp bindings-x86_64-unknown-freebsd/* ./npm/freebsd-x64/
 
diff --git a/crates/node/npm/linux-s390x-gnu/package.json b/crates/node/npm/linux-s390x-gnu/package.json
new file mode 100644
index 000000000000..b472dc9ba340
--- /dev/null
+++ b/crates/node/npm/linux-s390x-gnu/package.json
@@ -0,0 +1,30 @@
+{
+  "name": "@tailwindcss/oxide-linux-s390x-gnu",
+  "version": "4.3.2",
+  "repository": {
+    "type": "git",
+    "url": "git+https://github.com/tailwindlabs/tailwindcss.git",
+    "directory": "crates/node/npm/linux-s390x-gnu"
+  },
+  "os": [
+    "linux"
+  ],
+  "cpu": [
+    "s390x"
+  ],
+  "main": "tailwindcss-oxide.linux-s390x-gnu.node",
+  "files": [
+    "tailwindcss-oxide.linux-s390x-gnu.node"
+  ],
+  "publishConfig": {
+    "provenance": true,
+    "access": "public"
+  },
+  "license": "MIT",
+  "engines": {
+    "node": ">= 20"
+  },
+  "libc": [
+    "glibc"
+  ]
+}
diff --git a/crates/node/package.json b/crates/node/package.json
index 40ab70649739..ea6938d9fe34 100644
--- a/crates/node/package.json
+++ b/crates/node/package.json
@@ -16,6 +16,7 @@
       "aarch64-linux-android",
       "aarch64-apple-darwin",
       "aarch64-unknown-linux-gnu",
+      "s390x-unknown-linux-gnu",
       "aarch64-unknown-linux-musl",
       "armv7-unknown-linux-gnueabihf",
       "x86_64-unknown-linux-musl",
@@ -66,6 +67,7 @@
     "@tailwindcss/oxide-linux-arm-gnueabihf": "workspace:*",
     "@tailwindcss/oxide-linux-arm64-gnu": "workspace:*",
     "@tailwindcss/oxide-linux-arm64-musl": "workspace:*",
+    "@tailwindcss/oxide-linux-s390x-gnu": "workspace:*",
     "@tailwindcss/oxide-linux-x64-gnu": "workspace:*",
     "@tailwindcss/oxide-linux-x64-musl": "workspace:*",
     "@tailwindcss/oxide-wasm32-wasi": "workspace:*",