diff --git a/news/14187.feature.rst b/news/14187.feature.rst
new file mode 100644
index 0000000000..1471d35c6b
--- /dev/null
+++ b/news/14187.feature.rst
@@ -0,0 +1,3 @@
+Support ``--no-binary`` with ``-r pylock.toml``. Before, pip would get the
+sdist from the index instead of the locked URL, or fail if no wheel were
+available available in the lock file.
diff --git a/src/pip/_internal/cli/req_command.py b/src/pip/_internal/cli/req_command.py
index f58a970613..0e218ab5f2 100644
--- a/src/pip/_internal/cli/req_command.py
+++ b/src/pip/_internal/cli/req_command.py
@@ -368,7 +368,7 @@ def get_requirements(
                     "without prior warning."
                 )
                 for package, package_dist in select_from_pylock_path_or_url(
-                    filename, session=session
+                    filename, session=session, format_control=options.format_control
                 ):
                     req_to_add, locked_link = install_req_from_pylock_package(
                         package,
diff --git a/src/pip/_internal/utils/pylock.py b/src/pip/_internal/utils/pylock.py
index 70df98693b..ab1937efde 100644
--- a/src/pip/_internal/utils/pylock.py
+++ b/src/pip/_internal/utils/pylock.py
@@ -17,6 +17,7 @@
     Pylock,
     is_valid_pylock_path,
 )
+from pip._vendor.packaging.utils import NormalizedName
 from pip._vendor.packaging.version import Version
 
 from pip._internal.exceptions import DiagnosticPipError, InstallationError
@@ -25,6 +26,7 @@
 from pip._internal.utils.urls import path_to_url, url_to_path
 
 if TYPE_CHECKING:
+    from pip._internal.index.package_finder import FormatControl
     from pip._internal.network.session import PipSession
     from pip._internal.req.req_install import InstallRequirement
 
@@ -267,6 +269,7 @@ def _get_pylock_path_or_url_content(path_or_url: str, session: PipSession) -> st
 def select_from_pylock_path_or_url(
     pylock_path_or_url: str,
     session: PipSession,
+    format_control: FormatControl | None,
 ) -> Iterator[
     tuple[
         Package,
@@ -289,10 +292,16 @@ def select_from_pylock_path_or_url(
             f"Invalid pylock file {pylock_path_or_url!r}: {exc}"
         ) from exc
 
+    def prefer_sdist_predicate(name: NormalizedName) -> bool:
+        if format_control is None:
+            return False
+        allowed_formats = format_control.get_allowed_formats(name)
+        if "source" in allowed_formats and "binary" not in allowed_formats:
+            return True
+        return False
+
     try:
-        # TODO: for completeness, pylock.select should support preferring sdist
-        # over wheels to support --no-binary
-        yield from lock.select()
+        yield from lock.select(prefer_sdist_predicate=prefer_sdist_predicate)
     except Exception as exc:
         raise InstallationError(
             f"Cannot select requirements from pylock file {pylock_path_or_url!r}: {exc}"
diff --git a/tests/data/lockfiles/pylock.onepackage.toml b/tests/data/lockfiles/pylock.onepackage.toml
new file mode 100644
index 0000000000..d75d0d4a09
--- /dev/null
+++ b/tests/data/lockfiles/pylock.onepackage.toml
@@ -0,0 +1,19 @@
+lock-version = "1.0"
+created-by = "pip"
+
+[[packages]]
+name = "simplewheel"
+version = "2.0"
+
+[packages.sdist]
+path = "../packages/simplewheel-2.0.tar.gz"
+
+[packages.sdist.hashes]
+sha256 = "d1e1fceaf0b5eac764843e4a16ba62394a4fd85896c87a4439aab0af087af1ed"
+
+[[packages.wheels]]
+name = "simplewheel-2.0-1-py2.py3-none-any.whl"
+path = "../packages/simplewheel-2.0-1-py2.py3-none-any.whl"
+
+[packages.wheels.hashes]
+sha256 = "71e1ca6b16ae3382a698c284013f66504f2581099b2ce4801f60e9536236ceee"
diff --git a/tests/data/packages/simplewheel-2.0.tar.gz b/tests/data/packages/simplewheel-2.0.tar.gz
new file mode 100644
index 0000000000..a19138d193
Binary files /dev/null and b/tests/data/packages/simplewheel-2.0.tar.gz differ
diff --git a/tests/functional/test_install_pylock_reqs.py b/tests/functional/test_install_pylock_reqs.py
index 1f94754cd5..9b6bb5c2b9 100644
--- a/tests/functional/test_install_pylock_reqs.py
+++ b/tests/functional/test_install_pylock_reqs.py
@@ -208,6 +208,35 @@ def test_install_pylock_select_error(
     assert "Cannot select requirements from pylock file" in result.stderr
 
 
+def test_install_pylock_no_binary_selects_sdist(
+    script: PipTestEnvironment,
+    data: TestData,
+    tmp_path: Path,
+) -> None:
+    pylock_path = data.lockfiles.joinpath("pylock.onepackage.toml")
+    report = tmp_path / "report.json"
+    result = script.pip(
+        "install",
+        "--no-index",
+        "--find-links",
+        data.common_wheels,  # to obtain build backend to build sdist
+        "--dry-run",
+        "-r",
+        pylock_path,
+        "--no-binary=simplewheel",
+        "--report",
+        report,
+        allow_stderr_warning=True,
+    )
+    assert "experimental" in result.stderr
+    assert "Would install simplewheel-2.0" in result.stdout
+    # check that the sdist was selected
+    report_json = json.loads(report.read_text())
+    installed = report_json["install"]
+    assert installed[0]["metadata"]["name"] == "simplewheel"
+    assert installed[0]["download_info"]["url"].endswith(".tar.gz")
+
+
 def test_install_pylock_no_binary(
     script: PipTestEnvironment,
     data: TestData,