diff --git a/news/14122.bugfix.rst b/news/14122.bugfix.rst
new file mode 100644
index 0000000000..9d0f2e986a
--- /dev/null
+++ b/news/14122.bugfix.rst
@@ -0,0 +1,2 @@
+Improve cached wheel lookup performance when many cached wheels are checked
+for compatibility.
diff --git a/src/pip/_internal/cache.py b/src/pip/_internal/cache.py
index 0bcb697542..da2f8eb783 100644
--- a/src/pip/_internal/cache.py
+++ b/src/pip/_internal/cache.py
@@ -138,6 +138,7 @@ def get(
             return link
 
         canonical_package_name = canonicalize_name(package_name)
+        supported_tags_set = set(supported_tags)
         for wheel_name, wheel_dir in self._get_candidates(link, canonical_package_name):
             try:
                 wheel = Wheel(wheel_name)
@@ -152,7 +153,7 @@ def get(
                     package_name,
                 )
                 continue
-            if not wheel.supported(supported_tags):
+            if not wheel.supported(supported_tags_set):
                 # Built for a different python/arch/etc
                 continue
             candidates.append(