diff --git a/python/_re2.cc b/python/_re2.cc
index 22f092b2..20d9cfa5 100644
--- a/python/_re2.cc
+++ b/python/_re2.cc
@@ -38,6 +38,11 @@ namespace py = pybind11;
 // the py::buffer_info manages a reference count to the py::buffer, so it
 // must be constructed and subsequently destructed while holding the GIL.
 static inline absl::string_view FromBytes(const py::buffer_info& bytes) {
+  if (bytes.ndim != 1 || bytes.itemsize != 1 || bytes.strides.size() != 1 ||
+      bytes.strides[0] != 1) {
+    throw py::type_error(
+        "buffer must be a one-dimensional contiguous buffer of bytes");
+  }
   char* data = reinterpret_cast<char*>(bytes.ptr);
   ssize_t size = bytes.size;
   return absl::string_view(data, size);
diff --git a/python/re2_test.py b/python/re2_test.py
index 146b55b4..a8884723 100644
--- a/python/re2_test.py
+++ b/python/re2_test.py
@@ -301,6 +301,19 @@ def test_compile_with_latin1_encoding(self):
     # ... whereas this is fine, of course.
     re2.compile(b'.?', options=options)
 
+  def test_noncontiguous_buffer_rejected(self):
+    regexp = re2.compile(b'.')
+    for text in (memoryview(b'0123456789')[::-1],
+                 memoryview(b'0123456789')[::2]):
+      with self.assertRaisesRegex(
+          re2.error, 'one-dimensional contiguous buffer of bytes'):
+        regexp.search(text)
+
+    for pattern in (memoryview(b'.')[::-1], memoryview(b'..')[::2]):
+      with self.assertRaisesRegex(
+          re2.error, 'one-dimensional contiguous buffer of bytes'):
+        re2.compile(pattern)
+
   @parameterized.parameters(
       (u'\\p{Lo}', u'\u0ca0_\u0ca0', [(0, 1), (2, 3)]),
       (b'\\p{Lo}', b'\xe0\xb2\xa0_\xe0\xb2\xa0', [(0, 3), (4, 7)]),