diff --git a/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0-foss-2025b.eb b/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0-foss-2025b.eb
new file mode 100644
index 000000000000..c76d194cf065
--- /dev/null
+++ b/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0-foss-2025b.eb
@@ -0,0 +1,127 @@
+easyblock = 'PythonBundle'
+
+name = 'TensorFlow'
+version = '2.21.0'
+
+homepage = 'https://www.tensorflow.org/'
+description = "An open-source software library for Machine Intelligence"
+
+toolchain = {'name': 'foss', 'version': '2025b'}
+toolchainopts = {'pic': True}
+
+builddependencies = [
+    ('hatchling', '1.27.0'),
+    ('Bazel', '7.7.0', '-Java-21'),
+    # git 2.x required, see also https://github.com/tensorflow/tensorflow/issues/29053
+    ('git', '2.50.1'),
+    ('UnZip', '6.0'),
+    ('NASM', '2.16.03'),
+    # Required to build some of the extensions
+    ('poetry', '2.1.3'),
+    ('Cython', '3.2.4'),
+]
+
+dependencies = [
+    ('Python', '3.13.5'),
+    ('Python-bundle-PyPI', '2025.07'),
+    ('SciPy-bundle', '2025.07'),
+    ('h5py', '3.14.0'),
+    ('dill', '0.4.1'),
+    ('flatbuffers-python', '25.2.10'),
+    ('ml_dtypes', '0.5.3'),
+    ('patchelf', '0.18.0'),
+    ('protobuf-python', '6.31.1'),
+    ('grpcio', '1.81.0'),
+    ('wrapt', '1.17.3'),
+    ('Markdown', '3.8.2'),
+    ('absl-py', '2.3.1'),
+    ('tensorboard', '2.20.0'),
+    ('opt-einsum', '3.4.0'),
+    ('optree', '0.18.0'),
+    ('typing-extensions', '4.14.1'),
+]
+
+exts_list = [
+    ('astor', '0.8.1', {
+        'checksums': ['6a6effda93f4e1ce9f618779b2dd1d9d84f1e32812c23a29b3fff6fd7f63fa5e'],
+    }),
+    ('termcolor', '2.5.0', {
+        'checksums': ['998d8d27da6d48442e8e1f016119076b690d962507531df4890fcd2db2ef8a6f'],
+    }),
+    ('Werkzeug', '3.1.3', {
+        'source_tmpl': '%(namelower)s-%(version)s.tar.gz',
+        'checksums': ['60723ce945c19328679790e3282cc758aa4a6040e4bb330f53d30fa546d44746'],
+    }),
+    ('namex', '0.0.8', {
+        'checksums': ['32a50f6c565c0bb10aa76298c959507abdc0e850efe085dc38f3440fcb3aa90b'],
+    }),
+    ('keras', '3.13.2', {
+        'checksums': ['62f0123488ac87c929c988617e14f293f7bc993811837d08bb37eff77adc85a9'],
+    }),
+    ('google-pasta', '0.2.0', {
+        'modulename': 'pasta',
+        'checksums': ['c9f2c8dfc8f96d0d5808299920721be30c9eec37f2389f28904f454565c8a16e'],
+    }),
+    ('astunparse', '1.6.3', {
+        'checksums': ['5ad93a8456f0d084c3456d059fd9a92cce667963232cbf763eac3bc5b7940872'],
+    }),
+    ('tblib', '3.0.0', {
+        'checksums': ['93622790a0a29e04f0346458face1e144dc4d32f493714c6c3dff82a4adb77e6'],
+    }),
+    (name, version, {
+        'patches': [
+            'TensorFlow-2.4.0_dont-use-var-lock.patch',
+            'TensorFlow-2.21.0_disable-tf32-in-fused-matmul-tests.patch',
+            'TensorFlow-2.18.1_fix-xnnpack.patch',
+            'TensorFlow-2.18.1_fixedpoint.patch',
+            'TensorFlow-2.21.0_remove-libclang-dep.patch',
+            'TensorFlow-2.21.0_relax-flatbuffers-requirement.patch',
+        ],
+        'source_tmpl': 'v%(version)s.tar.gz',
+        'source_urls': ['https://github.com/tensorflow/tensorflow/archive/'],
+        'test_script': 'TensorFlow-2.x_mnist-test.py',
+        'test_tag_filters_cpu': '-gpu,-tpu,-no_cuda_on_cpu_tap,-no_pip,-no_oss,-oss_serial,-benchmark-test,-v1only',
+        'test_tag_filters_gpu': (
+            'gpu,-no_gpu,-nogpu,-gpu_cupti,-no_cuda11,'
+            '-no_pip,-no_oss,-oss_serial,-benchmark-test,-v1only'
+        ),
+        'test_targets': [
+            '//tensorflow/core/...',
+            '-//tensorflow/core:example_java_proto',
+            '//tensorflow/cc/...',
+            '//tensorflow/c/...',
+            '//tensorflow/python/...',
+            '-//tensorflow/c/eager:c_api_test_gpu',
+            '-//tensorflow/c/eager:c_api_distributed_test',
+            '-//tensorflow/c/eager:c_api_distributed_test_gpu',
+            '-//tensorflow/c/eager:c_api_cluster_test_gpu',
+            '-//tensorflow/c/eager:c_api_remote_function_test_gpu',
+            '-//tensorflow/c/eager:c_api_remote_test_gpu',
+            '-//tensorflow/core/common_runtime:collective_param_resolver_local_test',
+            '-//tensorflow/core/kernels/mkl:mkl_fused_ops_test',
+            '-//tensorflow/core/kernels/mkl:mkl_fused_batch_norm_op_test',
+            '-//tensorflow/core/ir/importexport/tests/roundtrip/...',
+        ],
+        'testopts': '--test_timeout=3600 --test_size_filters=small ',
+        'testopts_gpu': (
+            '--test_timeout=3600 --test_size_filters=small '
+            '--run_under=//tensorflow/tools/ci_build/gpu_build:parallel_gpu_execute '
+        ),
+        'with_xla': True,
+        'checksums': [
+            {'v2.21.0.tar.gz': 'ef3568bb4865d6c1b2564fb5689c19b6b9a5311572cd1f2ff9198636a8520921'},
+            {'TensorFlow-2.4.0_dont-use-var-lock.patch':
+             'b14f2493fd2edf79abd1c4f2dde6c98a3e7d5cb9c25ab9386df874d5f072d6b5'},
+            {'TensorFlow-2.21.0_disable-tf32-in-fused-matmul-tests.patch':
+             '2f605322c9694ccf6e013f06f403496320445a093ceca6625fec616343f5fd32'},
+            {'TensorFlow-2.18.1_fix-xnnpack.patch': 'baf81d7b2b61b5a923cf1f171d5e2400df6b8bd9073d3afa7a356e3bbe11984c'},
+            {'TensorFlow-2.18.1_fixedpoint.patch': '5ea1eb3b32e7df5f9ae711a71778b4cae544b3380f18882186eea035873fb640'},
+            {'TensorFlow-2.21.0_remove-libclang-dep.patch':
+             '4ee3773d07991c7f75d6dd4033ccf1bb9b017de478b39b4ffb6563a6bd66b981'},
+            {'TensorFlow-2.21.0_relax-flatbuffers-requirement.patch':
+             'c500796a1fe1f3de8322b1a1abeefbd3714fb255e6600d65e3815e20484c45ee'},
+        ],
+    }),
+]
+
+moduleclass = 'lib'
diff --git a/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0_disable-tf32-in-fused-matmul-tests.patch b/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0_disable-tf32-in-fused-matmul-tests.patch
new file mode 100644
index 000000000000..54ba997c9254
--- /dev/null
+++ b/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0_disable-tf32-in-fused-matmul-tests.patch
@@ -0,0 +1,44 @@
+Fixes failing FusedMatMul test on certain GPU models
+--- tensorflow/core/kernels/matmul_op_test.cc.orig	2026-06-29 00:00:00.000000000 +0200
++++ tensorflow/core/kernels/matmul_op_test.cc	2026-06-29 00:00:00.000000000 +0200
+@@ -24,7 +24,8 @@
+ #include "tensorflow/core/framework/tensor.h"
+ #include "tensorflow/core/framework/types.h"
+ #include "tensorflow/core/kernels/ops_testutil.h"
+ #include "tensorflow/core/lib/core/status_test_util.h"
++#include "tensorflow/core/platform/tensor_float_32_utils.h"
+ #include "tensorflow/core/platform/test.h"
+ #include "tensorflow/core/platform/test_benchmark.h"
+ #include "tensorflow/core/protobuf/rewriter_config.pb.h"
+@@ -334,6 +335,7 @@
+ // -------------------------------------------------------------------------- //
+ 
+ TYPED_TEST_P(FusedMatMulWithBiasOpTest, MatMul256x128x64) {
++  tensorflow::enable_tensor_float_32_execution(false);
+   this->VerifyMatMulWithBias(256, 128, 64, false, false);
+   this->VerifyMatMulWithBias(256, 128, 64, true, false);
+   this->VerifyMatMulWithBias(256, 128, 64, false, true);
+@@ -341,6 +343,7 @@
+ }
+ 
+ TYPED_TEST_P(FusedMatMulWithBiasOpTest, MatMul1x256x256) {
++  tensorflow::enable_tensor_float_32_execution(false);
+   this->VerifyMatMulWithBias(1, 256, 256, false, false);
+   this->VerifyMatMulWithBias(1, 256, 256, true, false);
+   this->VerifyMatMulWithBias(1, 256, 256, false, true);
+@@ -348,6 +351,7 @@
+ }
+ 
+ TYPED_TEST_P(FusedMatMulWithBiasOpTest, MatMul256x256x1) {
++  tensorflow::enable_tensor_float_32_execution(false);
+   this->VerifyMatMulWithBias(256, 256, 1, false, false);
+   this->VerifyMatMulWithBias(256, 256, 1, true, false);
+   this->VerifyMatMulWithBias(256, 256, 1, false, true);
+@@ -371,6 +375,7 @@
+ }
+ 
+ TYPED_TEST_P(FusedMatMulWithBiasOpTest, MatMul256x128x64WithActivation) {
++  tensorflow::enable_tensor_float_32_execution(false);
+   for (const std::string& activation : GetActivations(this->kTValueType)) {
+     this->VerifyConv2DWithBiasAndActivation(256, 128, 64, false, false,
+                                             activation);
diff --git a/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0_relax-flatbuffers-requirement.patch b/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0_relax-flatbuffers-requirement.patch
new file mode 100644
index 000000000000..89db20052730
--- /dev/null
+++ b/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0_relax-flatbuffers-requirement.patch
@@ -0,0 +1,15 @@
+TensorFlow 2.21.0 only uses flatbuffers as a Python runtime dependency in this
+EasyBuild configuration. Keep the wheel metadata compatible with the shared
+flatbuffers-python dependency used by other 2025b recipes.
+
+--- tensorflow/tools/pip_package/setup.py.tpl.orig	2026-06-29 00:00:00.000000000 +0200
++++ tensorflow/tools/pip_package/setup.py.tpl	2026-06-29 00:00:00.000000000 +0200
+@@ -97,7 +97,7 @@
+ REQUIRED_PACKAGES = [
+     'absl-py >= 1.0.0',
+     'astunparse >= 1.6.0',
+-    'flatbuffers >= 25.9.23',
++    'flatbuffers >= 25.2.10',
+     'gast >=0.2.1,!=0.5.0,!=0.5.1,!=0.5.2',
+     'google_pasta >= 0.1.1',
+     'libclang >= 13.0.0',
diff --git a/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0_remove-libclang-dep.patch b/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0_remove-libclang-dep.patch
new file mode 100644
index 000000000000..e5ac8082d89f
--- /dev/null
+++ b/easybuild/easyconfigs/t/TensorFlow/TensorFlow-2.21.0_remove-libclang-dep.patch
@@ -0,0 +1,17 @@
+libclang was introduced in
+https://github.com/tensorflow/tensorflow/commit/c211472000ff57bac7fcec9b0465cf73b37bf135
+> This is in preparation to open-source TF's TFRT backend.
+> TFRT generates code using libclang python bindings as part of the build.
+Hence it is not currently used and as it is not (easily) available for all architectures
+simply remove it.
+
+--- tensorflow/tools/pip_package/setup.py.tpl.orig	2026-06-29 00:00:00.000000000 +0200
++++ tensorflow/tools/pip_package/setup.py.tpl	2026-06-29 00:00:00.000000000 +0200
+@@ -97,7 +97,6 @@
+     'flatbuffers >= 25.9.23',
+     'gast >=0.2.1,!=0.5.0,!=0.5.1,!=0.5.2',
+     'google_pasta >= 0.1.1',
+-    'libclang >= 13.0.0',
+     'opt_einsum >= 2.3.2',
+     'packaging',
+     'protobuf >= 6.31.1, < 8.0.0',