diff --git a/packages/dd-trace/src/exporters/common/proxy.js b/packages/dd-trace/src/exporters/common/proxy.js
index 85274f42575..c928749803f 100644
--- a/packages/dd-trace/src/exporters/common/proxy.js
+++ b/packages/dd-trace/src/exporters/common/proxy.js
@@ -24,6 +24,8 @@ function getHttpsProxyAgent (url, directAgent) {
   const proxyUrl = getProxyForUrl(target)
   if (!proxyUrl) return directAgent
 
+  directAgent ??= require('node:https').globalAgent
+
   if (proxyAgents === undefined) {
     defaultAgentKey = {}
     proxyAgents = new WeakMap()
diff --git a/packages/dd-trace/src/opentelemetry/otlp/otlp_http_exporter_base.js b/packages/dd-trace/src/opentelemetry/otlp/otlp_http_exporter_base.js
index b5034396c7d..c98892027d0 100644
--- a/packages/dd-trace/src/opentelemetry/otlp/otlp_http_exporter_base.js
+++ b/packages/dd-trace/src/opentelemetry/otlp/otlp_http_exporter_base.js
@@ -6,7 +6,9 @@ const { URL } = require('node:url')
 const { storage } = require('../../../../datadog-core')
 const log = require('../../log')
 const { createServerlessDeliveryTracker } = require('../../serverless')
+const { getHttpsProxyAgent } = require('../../exporters/common/proxy')
 const telemetryMetrics = require('../../telemetry/metrics')
+const { version: tracerVersion } = require('../../../../../package.json')
 
 const tracerMetrics = telemetryMetrics.manager.namespace('tracers')
 const legacyStorage = storage('legacy')
@@ -48,8 +50,10 @@ class OtlpHttpExporterBase {
       hostname: parsedUrl.hostname,
       port: parsedUrl.port,
       path: parsedUrl.pathname + parsedUrl.search,
+      agent: parsedUrl.protocol === 'https:' ? getHttpsProxyAgent(parsedUrl) : undefined,
       headers: {
         'Content-Type': isJson ? 'application/json' : 'application/x-protobuf',
+        'User-Agent': `dd-trace-js/${tracerVersion}`,
         ...headers,
       },
     }
@@ -169,6 +173,7 @@ class OtlpHttpExporterBase {
     this.options.hostname = parsedUrl.hostname
     this.options.port = parsedUrl.port
     this.options.path = parsedUrl.pathname + parsedUrl.search
+    this.options.agent = parsedUrl.protocol === 'https:' ? getHttpsProxyAgent(parsedUrl) : undefined
     this.telemetryTags[0] = `protocol:${this.#transport === https ? 'https' : 'http'}`
   }
 
diff --git a/packages/dd-trace/test/opentelemetry/otlp/otlp_http_exporter_base.spec.js b/packages/dd-trace/test/opentelemetry/otlp/otlp_http_exporter_base.spec.js
new file mode 100644
index 00000000000..629af20ac13
--- /dev/null
+++ b/packages/dd-trace/test/opentelemetry/otlp/otlp_http_exporter_base.spec.js
@@ -0,0 +1,100 @@
+'use strict'
+
+const assert = require('node:assert/strict')
+const { describe, it, afterEach, beforeEach } = require('mocha')
+
+require('../../setup/core')
+
+const OtlpHttpExporterBase = require('../../../src/opentelemetry/otlp/otlp_http_exporter_base')
+const { version: tracerVersion } = require('../../../../../package.json')
+
+const proxyEnvironmentNames = [
+  'ALL_PROXY',
+  'HTTPS_PROXY',
+  'HTTP_PROXY',
+  'NO_PROXY',
+  'all_proxy',
+  'https_proxy',
+  'http_proxy',
+  'no_proxy',
+]
+
+describe('OtlpHttpExporterBase', () => {
+  let originalEnvironment
+
+  beforeEach(() => {
+    originalEnvironment = new Map()
+    for (const name of proxyEnvironmentNames) {
+      originalEnvironment.set(name, process.env[name])
+      delete process.env[name]
+    }
+  })
+
+  afterEach(() => {
+    for (const [name, value] of originalEnvironment) {
+      if (value === undefined) {
+        delete process.env[name]
+      } else {
+        process.env[name] = value
+      }
+    }
+  })
+
+  it('sends a User-Agent header identifying the tracer version', () => {
+    const exporter = new OtlpHttpExporterBase('https://intake.example/path', undefined, 1000, 'http/protobuf', 'traces')
+
+    assert.strictEqual(exporter.options.headers['User-Agent'], `dd-trace-js/${tracerVersion}`)
+  })
+
+  it('does not set an agent for an HTTPS endpoint when no proxy is configured', () => {
+    const exporter = new OtlpHttpExporterBase('https://intake.example/path', undefined, 1000, 'http/protobuf', 'traces')
+
+    assert.strictEqual(exporter.options.agent, undefined)
+  })
+
+  it('does not set an agent for an HTTP endpoint even when a proxy is configured', () => {
+    process.env.https_proxy = 'http://127.0.0.1:9999'
+
+    const exporter = new OtlpHttpExporterBase('http://intake.example/path', undefined, 1000, 'http/protobuf', 'traces')
+
+    assert.strictEqual(exporter.options.agent, undefined)
+  })
+
+  it('routes an HTTPS endpoint through the configured proxy agent', () => {
+    process.env.https_proxy = 'http://127.0.0.1:9999'
+
+    const exporter = new OtlpHttpExporterBase('https://intake.example/path', undefined, 1000, 'http/protobuf', 'traces')
+
+    assert.ok(exporter.options.agent)
+    assert.strictEqual(exporter.options.agent.proxy.hostname, '127.0.0.1')
+    assert.strictEqual(exporter.options.agent.proxy.port, '9999')
+  })
+
+  describe('setUrl', () => {
+    it('picks up a proxy agent when re-targeted to an HTTPS endpoint', () => {
+      const exporter = new OtlpHttpExporterBase(
+        'http://intake.example/path', undefined, 1000, 'http/protobuf', 'traces'
+      )
+      assert.strictEqual(exporter.options.agent, undefined)
+
+      process.env.https_proxy = 'http://127.0.0.1:9999'
+      exporter.setUrl('https://intake.example/other-path')
+
+      assert.ok(exporter.options.agent)
+      assert.strictEqual(exporter.options.agent.proxy.hostname, '127.0.0.1')
+      assert.strictEqual(exporter.options.agent.proxy.port, '9999')
+    })
+
+    it('clears the agent when re-targeted from HTTPS to HTTP', () => {
+      process.env.https_proxy = 'http://127.0.0.1:9999'
+      const exporter = new OtlpHttpExporterBase(
+        'https://intake.example/path', undefined, 1000, 'http/protobuf', 'traces'
+      )
+      assert.ok(exporter.options.agent)
+
+      exporter.setUrl('http://intake.example/other-path')
+
+      assert.strictEqual(exporter.options.agent, undefined)
+    })
+  })
+})